Dr. Mehrpouyan's research focuses on ensuring privacy, security, and robustness of mission-critical cyber-physical systems. On April 2019, she was the recipient of the CAREER award, which is the National Science Foundation's most prestigious awards given to junior faculty who have the potential to serve as academic role models in research and education and to lead advances in the mission of their organization.

Her research focus on developing a multi-layer security tools and algorithms to provide control technicians and engineers with far superior mechanisms to address the increasing risk of cybersecurity attacks and reduce latent risks to public health and safety, industry, and national security. The findings will generate knowledge base and forensic tools to help control engineers to quickly detect and mitigate potential security flaws in central components across control systems, including industrial control software, sensors, and actuators.